Abstract
The myo-inositol transport system in kidney plasma mambrane preparation was investigated. myo-Inisitol uptake was more rapid than that due to non-specific uptake. Specific myo-inisitol uptake was temperature dependent and pH sensitive; the optimum was at pH 7.4. Specific myo-insitol uptake was inhibited by scyllitol and inosose-2 but not(+)-inositol, d-glucose, d-galactose or mannitol. Inhibition of myo-inositol uptake by scyllitol was of the competitive type. It showed that the transport system is stereospecific and that myo-inositol shares the transport system with scyllitol. Moreover, the specific myo-inositol uptake was inhibited by phlorizin. Counter transport of myo-inositol was demonstrated. The results indicate that myo-inositol uptake by the membrane preparation represents the entry into the intravesicular spaces rather than binding to the membrane. It was concluded that the plasma membrane of rat kidney has a cyclitol carrier system specific to myo-inositol and scyllitol.
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