Abstract
Hamartomas of the breast, also known as fibroadenolipomas, lipofibroadenomas or adenolipomas, are benign lesions. Hamartomas account for between 0.04 and 1.15% of all benign breast tumors in females. Myoid hamartoma of the breast (MHB) is extremely rare. The present study describes a case of MHB in a 44-year-old female. Screening mammography revealed a lobulated partial indistinct isodense mass measuring ~3.8 cm in the upper outer quadrant of the left breast. Sonographic examinations revealed a 2–3-cm mass in the left breast, which was fairly well circumbscribed and demonstrated complex scattered echogenic areas and isoechoic tissue. A core needle biopsy demonstrated fibrocystic changes, with small focal ductule aggregations. As malignancy could not be excluded, a partial mastectomy was performed using a circumareolar incision. The mass was histopathologically diagnosed as MHB with focal chondromyoxid metaplasia and pseudoangiomatous stromal hyperplasia. The histological diagnosis was based upon the findings of the well-circumscribed tumor, which was composed of entrapped mammary ducts, fat cells and myoid stromal components, with focal chondromyxoid metaplasia and pseudoangiomatous stromal hyperplasia. The tumor cells exhibited diffuse cluster of differentiation 34-positive immunoreactivity, which was consistent with a diagnosis of pseudoangiomatous stromal hyperplasia.
Highlights
Hamartomas of the breast, known as fibroadenolipomas, lipofibroadenomas or adenolipomas, are benign lesions that were first described in 1971 [1]
Myoid hamartomas may present as painless breast lumps, using sonography it has been revealed that the majority of hamartomas are hyperechoic or composed of mixed echogenicity, retrotumor acoustic phenomena are absent
Breast hamartomas are rare lesions, that may be misdiagnosed pre‐operatively, with a definitive diagnosis made by histological examination
Summary
Hamartomas of the breast, known as fibroadenolipomas, lipofibroadenomas or adenolipomas, are benign lesions that were first described in 1971 [1]. Myoid hamartoma of the breast is composed of differentiated mammary glandular and stromal structures and is considered to be a rare variant of mammary hamartoma. A physical examination revealed the presence of a mass measuring ~3 cm in diameter in the upper outer quadrant (UOQ) of the left breast. Mammographical examinations performed to rule out malignancy revealed a lobulated partial indistinct isodense mass measuring ~3.8 cm in the UOQ of the left breast (Fig. 1) and suggested that further evaluation and tissue examinations were necessary. Ultrasonography examinations revealed a ~2.42x2.17x1.36 cm mass in the left breast, which was fairly well‐circumscribed and demonstrated complex scattered echogenic areas and isoechoic tissue, which was consistent. A diagnosis of myoid hamartoma with focal chondromyxoid differentiation and pseudoangiomatous stromal hyperplasia was established
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