Abstract
Production of myocardial lesions with sympathomimetic a mines was studied in rats. Subcutaneous administration of isoproterenol at the daily doses of 1.2mg and 0.7mg per kg for 14 days caused a marked diffuse myocarditis. The myocardial lesions were detected by electrocardiogram 1 week after the begin-ning of the administration. Norepinephrine, nor-fenefrine and phenylephrine did not show any pathologic change in the myocardium. The significance of the toxic effects of these a mines was studied.
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