Abstract
Background CMR is a recognized method of assessing global RV function in patients with pulmonary arterial hypertension (PAH). Unfortunately, assessment of regional myocardial motion with MRI remains challenging due to the thin RV wall. One solution may be tissue phase mapping (TPM) in which motion can be encoded at a higher spatial resolution. However, one problem is the need for respiratory navigation due to long scan times. We have therefore implemented a novel self-gated golden-angle spiral TPM technique that can acquire high-resolution data efficiently during free breathing in healthy volunteers and in patients with PAH. Methods
Highlights
CMR is a recognized method of assessing global RV function in patients with pulmonary arterial hypertension (PAH)
Quantification revealed lower peak radial s-wave velocity in PAH compared to controls (1.5 cm/s ± 1.3 versus 2.3 ± 1.6, p < 0.02), as well as lower radial e-wave (1.2 ± 1.8 vs 2.4 ± 2.5, p < 0.03) and longitudinal e-wave (2.8 ± 3.5 vs 5.0 ± 3.2, p < 0.004) velocities
In patients with PAH, RV contraction was significantly prolonged compared to LV contraction, both radially (46% ± 18 vs 42% ± 14 of cardiac cycle, p = 0.016) and longitudinally (39% ± 11 vs 33% ± 18, p = 0.013)
Summary
CMR is a recognized method of assessing global RV function in patients with pulmonary arterial hypertension (PAH). Assessment of regional myocardial motion with MRI remains challenging due to the thin RV wall. One solution may be tissue phase mapping (TPM) in which motion can be encoded at a higher spatial resolution. One problem is the need for respiratory navigation due to long scan times.
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