Abstract
Background Myocardial vasodilator reserve is an important surrogate marker of normal and abnormal cardiac physiology. Pharmacological vasodilator agents such as adenosine increase myocardial blood volume, which is expected to prolong the observed T1-relaxation. We explored the novel application of stress T1-mapping by assessing the response of myocardial T1 to the administration of adenosine in healthy volunteers.
Highlights
Myocardial vasodilator reserve is an important surrogate marker of normal and abnormal cardiac physiology
We explored the novel application of stress T1-mapping by assessing the response of myocardial T1 to the administration of adenosine in healthy volunteers
Mean T1 values were derived for whole-heart, per-slice and segmental analyses (AHA 16-segment model)
Summary
Myocardial vasodilator reserve is an important surrogate marker of normal and abnormal cardiac physiology. Pharmacological vasodilator agents such as adenosine increase myocardial blood volume, which is expected to prolong the observed T1-relaxation. We explored the novel application of stress T1-mapping by assessing the response of myocardial T1 to the administration of adenosine in healthy volunteers
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