Abstract
BackgroundCoronary artery disease (CAD) is one of the most prevalent diseases around the world; however, finding the best noninvasive, low-cost, and more easily accessible test for its screening has been a challenge for several years. Eighty-nine patients suspected of stable CAD underwent 2D-speckle-tracking echocardiography (2DSTE) at resting position and offline longitudinal myocardial strain analysis, followed by coronary angiography. The correlation of the global longitudinal strain (GLS) and territorial longitudinal strain (TLS) with significant CAD (70% and more stenosis in at least one coronary artery) was then evaluated.ResultsThe statistical analysis showed a significant correlation between low GLS and significant CAD (P=0.0001). The results also showed a significant correlation between low TLS and significant CAD in the left and right coronary artery territories. The optimal cut-off point of GLS for the detection of significant CAD was −19.25, with a sensitivity of 76.5% and specificity of 76.6%.ConclusionThis study confirmed the usefulness of 2DSTE myocardial strain analysis in diagnosis of CAD for detecting the affected coronary arteries using GLS and SLS.
Highlights
Coronary artery disease (CAD) is one of the most prevalent diseases around the world; finding the best noninvasive, low-cost, and more accessible test for its screening has been a challenge for several years
Myocardial strain analysis with 2D-speckle-tracking echocardiography (2DSTE), which is performed at resting position, offers valuable information about myocardial fiber changes in different types of myocardial diseases [6,7,8]
Study design The exclusion criteria were considered as following age below 18 years, a left ventricular ejection fraction
Summary
Coronary artery disease (CAD) is one of the most prevalent diseases around the world; finding the best noninvasive, low-cost, and more accessible test for its screening has been a challenge for several years. Eighty-nine patients suspected of stable CAD underwent 2D-speckle-tracking echocardiography (2DSTE) at resting position and offline longitudinal myocardial strain analysis, followed by coronary angiography. Exercise tests are the first-line screening for most patients, but lower sensitivity and specificity sometimes limited them in CAD diagnosis even combined with myocardial perfusion imaging or echocardiogram. These tests are not practical for patients with mobility issues [4, 5]. Myocardial strain analysis with 2D-speckle-tracking echocardiography (2DSTE), which is performed at resting position, offers valuable information about myocardial fiber changes in different types of myocardial diseases [6,7,8]. Despite Doppler tissue imaging (DTI), 2DSTE is not influenced by noises or adjacent segment tethering and is not angle-dependent [10,11,12,13]
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