Abstract
Background Patients with diabetes mellitus (DM) of longer duration have an increased incidence of heart failure, independent of hypertension and coronary disease, as shown in large population based studies. Mechanisms of diabetic cardiomyopathy are multifactorial and not fully elucidated. Cardiovascular magnetic resonance (CMR) and magnetic resonance spectrocopy (MRS) provide a noninvasive assessment of the functional, structural and metabolic status of the heart. Here we assessed whether subclinical functional, structural and metabolic alterations can be detected using MRI in a patient cohort of early-onset, stable and uncomplicated type 2 DM. Objective The aim of this study was to assess the earliest manifestations of diabetic cardiomyopathy using multiparametric CMR and MRS in a cohort of uncomplicated type 2 DM patients with a short duration of disease. Methods
Highlights
Patients with diabetes mellitus (DM) of longer duration have an increased incidence of heart failure, independent of hypertension and coronary disease, as shown in large population based studies
Diabetic patients were well-matched with controls (Figure 1)
Myocardial energetics were disturbed (PCr/ ATP ratio: 1.44 ± 0.35 vs. 1.98 ± 0.18, p < 0.001) and myocardial triglyceride content increased (1.06 ± 0.61 vs. 0.48 ± 0.24%, p = 0.01), despite the relatively short disease duration
Summary
Patients with diabetes mellitus (DM) of longer duration have an increased incidence of heart failure, independent of hypertension and coronary disease, as shown in large population based studies. Mechanisms of diabetic cardiomyopathy are multifactorial and not fully elucidated. Cardiovascular magnetic resonance (CMR) and magnetic resonance spectrocopy (MRS) provide a noninvasive assessment of the functional, structural and metabolic status of the heart. We assessed whether subclinical functional, structural and metabolic alterations can be detected using MRI in a patient cohort of early-onset, stable and uncomplicated type 2 DM
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