Myocardial salvaging effect of turmeric (Curcuma longa) on experimentally induced myocardial injury in rats

Abstract

Background: In Ayurveda turmeric (Curcuma longa) has been used for cardioprotection. Experimentally induced myocardial injury is clinically similar to human myocardial infarction. Objective: The study was designed to assess the myocardial salvagingeffect of turmeric (Curcuma longa) on experimentally induced myocardial injury in rats. Methods: This experimental study was carried out in the Department of Physiology, Dhaka Medical College, Dhaka during 2015. Total twenty eight (28) Wistar albino male rats (aged 13±1 weeks; 125±25 gm) were randomly grouped into NS (normal control group), ISO (isoproterenol treated control group),Tm+ISO (turmeric pretreated and isoproterenol treated group) and Am+ISO (amlodipine pretreated and isoproterenol treated group). All the rats were sacrificed on 10th day of experimentation. . Blood samples were collected. Serum carduac troponin I (cTnI) level was estimated by AxSYM methodand serum malondialdehyde (MDA) level was estimated byspectrophotometric method.For statistical analysis, one way ANOVA followed by Bonferroni post hoc test was done by using SPSS 22.0 version. Results: The mean serum cTnI and MDA level was significantly (P<0.001) higher in ISO in comparison to all other rats of different groups. Whereas, the mean serum cTnI level was lower in Tm+ISO and Am+ISO in comparison to that of ISO which were statistically significant (P<0.05). Again, mean serum MDA level was significantly lower in Tm+ISO(P<0.05) and Am+ISO(P<0.001) in comparison to that of ISO.However, there were no significant differences between Tm+ISO and Am+ISO. Conclusion: The results of the study concluded that turmeric has myocardial salvaging effect on experimentally induced myocardial injury inrats. J Bangladesh Soc Physiol. 2022, June; 17(1): 34-40