Abstract
Myocardial progenitor cells represent a perspective source for cell therapy of cardiovascular disorders and are intensively studied. However, mainly the cells from adult patients are studied whereas the cells derived from children with congenital heart diseases remained poorly investigated. The aim of the present work was to obtain progenitor cells from intraoperatively obtained cardiac tissue from infants and children undergoing repair of congenital cardiac defects. Following isolation, the cells gave rise to a clonogenic, highly proliferative spindle-shaped cell population. The cells expressed markers of cardiogenic origin and were shown to differentiate towards cardiogenic lineage. This resident myocardial progenitor cells obtained from infant myocardial tissue demonstrate similar characteristics to previously described cells derived from adult myocardial tissue. This study confirms the possibility of obtaining a pool of progenitor cells from tiny tissue fragments and opens a new perspective of using these cells in regenerative medicine and further research of congenital heart disease pathogenesis.
Highlights
2 Saint-Petersburg State University, 199034, Universitetskaya nab., 7-9, St. Petersburg, Russia 3 Institute of Cytology Russian Academy of Science , 194064, Tikhoretsky ave
Mainly the cells from adult patients are studied whereas the cells derived from children with congenital heart diseases remained poorly investigated
The cells expressed markers of cardiogenic origin and were shown to differentiate towards cardiogenic lineage. This resident myocardial progenitor cells obtained from infant myocardial tissue demonstrate similar characteristics to previously described cells derived from adult myocardial tissue
Summary
2 Saint-Petersburg State University, 199034, Universitetskaya nab., 7-9, St. Petersburg, Russia 3 Institute of Cytology Russian Academy of Science , 194064, Tikhoretsky ave. Abstract Myocardial progenitor cells represent a perspective source for cell therapy of cardiovascular disorders and are intensively studied.
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