Abstract
Summary In the current study, we prospectively compared the diagnostic value of SW-CG-HYPR and conventional SRTurbo-FLASH for myocardial perfusion MRI in patients with suspected CAD. Compared with conventional SRTurbo-FLASH, SW-CG-HYPR allows increased spatial coverage (whole left ventricular coverage), improved temporal and spatial resolution and SNR, reduced motion artifacts and has higher diagnostic accuracy in patients with suspected CAD. Background A sliding-window (SW) conjugate-gradient (CG) highly constrained back-projection reconstruction (HYPR) (SW-CG-HYPR) technique has been developed for timeresolved myocardial perfusion imaging. Using this method, the acquisition time per cardiac cycle can be reduced dramatically while maintaining the temporal resolution of one frame per heartbeat in myocardial perfusion MRI, allowing increased spatial coverage (whole left ventricular coverage), improved temporal and spatial resolution and SNR, and reduced motion artifacts compared with the conventional SR-Turbo-FLASH sequence. However, the diagnostic accuracy of myocardial perfusion MRI with SW-CG-HYPR for detecting coronary artery disease (CAD) has not been directly compared to that with conventional SR-Turbo-FLASH. The purpose of this study was to prospectively compare the diagnostic value of SW-CG-HYPR and conventional SR-Turbo-FLASH for myocardial perfusion MRI in patients with suspected CAD. Methods
Highlights
Summary In the current study, we prospectively compared the diagnostic value of SW-CG-highly constrained back-projection reconstruction (HYPR) and conventional SRTurbo-FLASH for myocardial perfusion MRI in patients with suspected coronary artery disease (CAD)
A sliding-window (SW) conjugate-gradient (CG) highly constrained back-projection reconstruction (HYPR) (SW-CG-HYPR) technique has been developed for timeresolved myocardial perfusion imaging
The acquisition time per cardiac cycle can be reduced dramatically while maintaining the temporal resolution of one frame per heartbeat in myocardial perfusion MRI, allowing increased spatial coverage, improved temporal and spatial resolution and SNR, and reduced motion artifacts compared with the conventional SR-Turbo-FLASH sequence
Summary
Myocardial perfusion MRI with SW-CG-HYPR: a comparison to conventional SR-Turbo-FLASH and x-ray angiography in patients with suspected coronary artery disease. Heng Ma1,2*, Jun Yang, Jing Liu, Lan Ge3, David Chen, Kai Lin, Jing An4, Lixin Jin, Kuncheng Li2, Debiao Li3. Summary In the current study, we prospectively compared the diagnostic value of SW-CG-HYPR and conventional SRTurbo-FLASH for myocardial perfusion MRI in patients with suspected CAD. Compared with conventional SRTurbo-FLASH, SW-CG-HYPR allows increased spatial coverage (whole left ventricular coverage), improved temporal and spatial resolution and SNR, reduced motion artifacts and has higher diagnostic accuracy in patients with suspected CAD
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