Abstract
Methods We conducted a prospective study of 25 renal transplant (RT) recipients, 8 liver transplant (LT) recipients without previous CKD history and 7 controls with hypertension (HT). The transplant recipients were asymptomatic and had no previous ischaemic heart disease or revascularisation or systolic heart failure. The pre-transplant workup of the RT and LT were negative for haemodynamically significant epicardial coronary artery stenosis. Diabetes mellitus history between RT, LT and HT controls were not statistically different. Myocardial function, late-gadolinium enhancement and first-pass perfusion was assessed semiquantitatively at rest and under stress. The MPRI was calculated as the ratio of perfusion during adenosine-induced hyperemia to the rest perfusion. The RT and LT patients underwent whole-heart non-contrast magnetic resonance coronary angiography (MRCA) to assess the presence of proximal to mid epicardial coronary artery disease.
Highlights
Myocardial perfusion is impaired in renal transplant and liver transplant patients Susie F Parnham4,5, Jonathan M Gleadle1,6, Darryl Leong2, Suchi Grover5, Craig Bradbrook3, Richard J Woodman7, Carmine De Pasquale5,6, Joseph Selvanayagam5,4*
Cardiovascular disease is a common cause of mortality post renal transplantation, often manifesting in patients with no known cardiac disease
We hypothesised that myocardial perfusion reserve would be impaired in renal transplant recipients compared with hypertensive controls, and similar to liver transplant recipients
Summary
Cardiovascular disease is a common cause of mortality post renal transplantation, often manifesting in patients with no known cardiac disease. The cardiac phenotype in these patients is not clearly defined. We hypothesised that myocardial perfusion reserve would be impaired in renal transplant recipients compared with hypertensive controls, and similar to liver transplant recipients
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