Abstract
Objective: To evaluate the myocardial performance index (MPI) in sickle cell disease (SCD) patients, and to compare MPI in healthy individuals.Methods: In this case-controlled study, patients of SCD and age- and sex-matched controls were included. MPI was determined using echocardiographic Doppler-derived parameters. MPI according to disease type, sickle cell crisis, and in the presence of co-morbidities was compared. Results: Between October 2018 and September 2020, we enrolled 100 SCD patients and 100 age and sex-matched controls. The MPI was significantly higher in SCD than in the control group (0.411±0.028 vs. 0.387±0.015, respectively; p<0.0001). There was no difference in MPI according to disease type as SS or AS (p=0.903). In patients with sickle cell crisis, mean MPI was significantly higher than those without sickle cell crisis (0.443±0.003 vs. 0.403±0.025, respectively; p<0.0001). In patients with comorbidities, mean MPI was significantly higher than those without any comorbidity (0.432±0.021 vs. 0.404±0.026, respectively; p<0.0001).Conclusion: MPI can be a non-invasive tool for assessing subclinical cardiac dysfunction and should be considered for evaluating patients with SCD.
Highlights
Sickle cell disease (SCD) is the second most common haemoglobinopathy [1]
The myocardial performance index (MPI) was significantly higher in SCD than in the control group (0.411±0.028 vs. 0.387±0.015, respectively; p
SCD is associated with a variety of complications of the CV system ranging from elevated pulmonary artery systolic pressure, pulmonary hypertension (PHT), dysrhythmia, cardiomyopathies, and sudden cardiac death
Summary
Sickle cell disease (SCD) is the second most common haemoglobinopathy [1]. Among countries in the low‐ income category, up to 80% of SCD cases remain undiagnosed, and
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