Abstract
Diabetic patients develop cardiomyopathy, characterized mainly by left ventricular contractile dysfunction and congestive heart failure. Vitamin E-quinone and lipid peroxidation levels in the heart ventricles are signi ficantly higher in diabetic rats compared with control rats. This increase was prevented in insulin-treated diabetic rats. Hyperglycemia can generate oxygen radicals and cause membrane lipid peroxidation in the myocardium. Lipid peroxidation and its products can cause hyperviscosity and hypercoagulability of blood, and oxidative modification of lipoproteins. This can result in altered blood, and atherosclerosis. On the other hand, lipid peroxides can inhibit prostacyclin synthetase and causes imbalance in the prostacyclin and thromboxane levels, which can induce vasoconstriction. Thus, increased lipid peroxidation may have a role in the altered contractile property of heart ventricles and the development of cardiomyopathy associated with diabetes.
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