Abstract
Background In recent years, ischemic preconditioning(IPC) has been widely stuided. The ATP-sensitive potassium channel(KATP), which acts as a key end-effector in the pathways of intracellular signaling transduction, has gained wide attention because of its important role in the IPC. Objective To further clarify the pathophysiology of the IPC and provide theoretical basis for clinical work. Content This article reviews the research progress of the sarcolemmal ATP-sensitive potassium channel (sarcKATP) as well as its role in myocardial IPC. This article reviews the physiological characteristics of the sarcolemmal ATP-sensitive potassium channels (sarcKATP) channel, its role in myocardial IPC as well as its regulatory mechanism. Trend Regulating sarcKATP-targeted study is promising candidate for IPC. Key words: ATP-sensitive potassium channels; Ischemic preconditioning; Cardioprotection
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Anesthesiology and Resuscitation
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
