Abstract
Myocardial injury in hospitalized patients is associated with poor prognosis. This study aimed to evaluate risk factors for myocardial injury in hospitalized patients with coronavirus disease 2019 (COVID-19) and its prognostic value. We retrieved all consecutive patients who were hospitalized in internal medicine departments in a tertiary medical center from February 9th, 2020 to August 28th with a diagnosis of COVID-19. A total of 559 adult patients were hospitalized in the Sheba Medical Center with a diagnosis of COVID-19, 320 (57.24%) of whom were tested for troponin levels within 24-hours of admission, and 91 (28.44%) had elevated levels. Predictors for elevated troponin levels were age (odds ratio [OR], 1.04; 95% confidence interval [CI], 1.01–1.06), female sex (OR, 3.03; 95% CI 1.54–6.25), low systolic blood pressure (OR, 5.91; 95% CI 2.42–14.44) and increased creatinine level (OR, 2.88; 95% CI 1.44–5.73). The risk for death (hazard ratio [HR] 4.32, 95% CI 2.08–8.99) and a composite outcome of invasive ventilation support and death (HR 1.96, 95% CI 1.15–3.37) was significantly higher among patients who had elevated troponin levels. In conclusion, in hospitalized patients with COVID-19, elevated troponin levels are associated with poor prognosis. Hence, troponin levels may be used as an additional tool for risk stratification and a decision guide in patients hospitalized with COVID-19.
Highlights
The coronavirus disease 2019 (COVID-19) pandemic is a global health concern
We examined other outcomes, including the death within 60 days of hospitalization; intubation within 30 days from admission, which includes only the patients who were intubated during the first hospitalization with COVID-19 in The Sheba Medical Center; length of hospital stay; hypoxemia during hospitalization, defined as a measurement of oxygen saturation
In this retrospective cohort study, we demonstrated factors that are associated with elevated troponin in patients with COVID-19, and showed that elevated troponin is associated with a poor prognosis in patients hospitalized with COVID-19
Summary
Its main manifestation is pulmonary inflammation with potentially life-threatening complications, such as pneumonia and acute respiratory distress syndrome [1,2,3]. Several studies have described myocardial injury in patients diagnosed with COVID-19 [1, 9,10,11,12,13,14,15,16,17]. According to these studies, COVID-19 complications such as acute respiratory distress syndrome, acute kidney injury were more common in patients with.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
