Abstract
Although optimal therapy for myocardial infarction includes reperfusion to restore blood flow to the ischemic region, ischemia/reperfusion (IR) also initiates an inflammatory response likely contributing to adverse left ventricular (LV) extracellular matrix (ECM) remodeling. Galectin-3 (Gal-3), a β-galactoside-binding-lectin, promotes cardiac remodeling and dysfunction. Our aim is to investigate whether Gal-3 pharmacological inhibition using modified citrus pectin (MCP) improves cardiac remodeling and functional changes associated with IR. Wistar rats were treated with MCP from 1 day before until 8 days after IR (coronary artery ligation) injury. Invasive hemodynamics revealed that both LV contractility and LV compliance were impaired in IR rats. LV compliance was improved by MCP treatment 8 days after IR. Cardiac magnetic resonance imaging showed decreased LV perfusion in IR rats, which was improved with MCP. There was no difference in LV hypertrophy in MCP-treated compared to untreated IR rats. However, MCP treatment decreased the ischemic area as well as Gal-3 expression. Gal-3 blockade paralleled lower myocardial inflammation and reduced fibrosis. These novel data showing the benefits of MCP in compliance and ECM remodeling in IR reinforces previously published data showing the therapeutic potential of Gal-3 inhibition.
Highlights
To that purpose, we evaluated the early benefits of Gal-3 inhibition on cardiac functional, histological and molecular alterations in the rat model of IR
In modified citrus pectin (MCP) treated compared to untreated IR rats, a trend toward the improvement of the left ventricular (LV) filling pressure i.e. LV end-diastolic pressure (LVEDP) (Fig. 1A,B) paralleled clear amelioration of the calculated LV compliance in diastole (LVEDPVR; Fig. 1C,D)
This study demonstrates that pharmacological Gal-3 blockade induced cardioprotection during IR injury, improving LV perfusion and compliance
Summary
Our aim is to investigate whether Gal-3 pharmacological inhibition using modified citrus pectin (MCP) improves cardiac remodeling and functional changes associated with IR. The purpose of this study was to investigate the effects of Gal-3 inhibition in cardiac alterations associated to IR injury
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