Abstract
Background It has been suggested that the angiotensinogen (AGT) gene rs4762 (p.Thr174Met) polymorphism might be associated with myocardial infarction (MI) risk, but the study results are still debatable. Objective and Methods. In order to explore the relationship between AGT p.Thr174Met polymorphism and MI risk, the current meta-analysis involving 7657 subjects from 11 individual studies was conducted. Results A significant association between AGT p.Thr174Met polymorphism and MI was found under recessive (OR: 2.26, 95% CI: 1.35-3.77, P = 0.002), dominant (OR: 1.131, 95% CI: 1.016-1.260, P = 0.024), codominant (OR: 2.198, 95% CI: 1.334-3.621, P = 0.002), and additive (OR: 1.363, 95% CI: 1.132-1.641, P = 0.001) genetic models. In the Asian subgroup, significantly increased MI risk was found under all genetic models (P < 0.05). No significant association between AGT p.Thr174Met polymorphism and MI was found under all genetic models in the Caucasian subgroup (P > 0.05). Conclusions AGT p.Thr174Met variant might increase MI risk, especially within the Asian population. The Met174 allele of AGT p.Thr174Met might confer the risk for MI.
Highlights
Myocardial infarction (MI) is a serious type of coronary artery disease (CAD) that has high morbidity and mortality rates [1, 2]
myocardial infarction (MI) may be caused by coronary artery critical stenosis or occlusion and myocardial ischemic necrosis based on coronary artery atherosclerosis; the pathogenesis has not yet been completely clarified [3, 4]
In the past few years, many studies that investigated the relationship between gene polymorphisms and MI focused primarily on enzymes and key proteins related to the regulation and metabolism of the cardiovascular system
Summary
It has been suggested that the angiotensinogen (AGT) gene rs4762 (p.Thr174Met) polymorphism might be associated with myocardial infarction (MI) risk, but the study results are still debatable. A significant association between AGT p.Thr174Met polymorphism and MI was found under recessive (OR: 2.26, 95% CI: 1.35-3.77, P = 0:002), dominant (OR: 1.131, 95% CI: 1.016-1.260, P = 0:024), codominant (OR: 2.198, 95% CI: 1.334-3.621, P = 0:002), and additive (OR: 1.363, 95% CI: 1.132-1.641, P = 0:001) genetic models. In the Asian subgroup, significantly increased MI risk was found under all genetic models (P < 0:05). No significant association between AGT p.Thr174Met polymorphism and MI was found under all genetic models in the Caucasian subgroup (P > 0:05). AGT p.Thr174Met variant might increase MI risk, especially within the Asian population. The Met174 allele of AGT p.Thr174Met might confer the risk for MI
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