Abstract
Through a previously implanted catheter, normothermic normal saline solution was infused into the pericardial sacs of dogs. Sufficient pericardial tamponade was induced to lower the arterial pressure from an average control of 160/112 mm. Hg to an average of 97/69. Tamponade was maintained for 6 hours during constant monitoring of arterial, central venous, and pericardial pressures. During the 72 hours following tamponade, serial determinations of serum creatine phosphokinase, serum glutamic oxaloacetic transaminase, and lactic dehydrogenase were made. At 72 hours the animals were sacrificed and their hearts studied for gross and microscopical myocardial pathology. All experimental animals showed striking enzyme elevations, and 6 of 10 had visible myocardial necrosis. Correlation between elevations of serum CPK and central venous and pericardial pressures with the degree of myocardial necrosis was significant at the p < 0.005, < 0.009, and < 0.013 levels, respectively. Prolonged pericardial tamponade may result in significant myocardial necrosis, which suggests coronary artery insufficiency and myocardial hypoxia as a cause.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.