Abstract
culated, and two novel indices of ventricular compliance; LV circumferential (CRI) and longitudinal (LRI) relaxation indices. Results: LV EF was significantly lower in ICM (32± 2 vs 65± 2, p< 0.001) and hyperdynamic in HCM (72± 2 vs 65± 2, p= 0.03) when compared to VOL. SV was similar in all groups. ICM LV EDV was 1.8× greater than VOL (p< 0.001) and 2.2× greater than HCM (p< 0.001). CRI was impaired in ICM patients (19% lower than VOL, p< 0.001) and preserved in HCM. LRI was significantly lower in ICM (72% lower, p< 0.001) and HCM patients (50% lower, p< 0.001) when compared to VOL. Atrial EF was significantly lower in both ICM (22.6± 10.2) andHCM (28.8± 10.5) than VOL (49.1± 9.1, p< 0.001). Conclusions: This work demonstrates cMRI is capable of producing measures of diastolic function, which are at least comparable with current techniques in echocardiography. Using novel LR and CR indices, we have shown that impairment of diastolic function is primarily due to abnormal relaxation of LV longitudinal fibers and that this maybe compensated for byhyperdynamic circumferential fibers in order to maintain SV. doi:10.1016/j.hlc.2011.05.452
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