Abstract
Myocardial necrosis was produced in rats by administering isoproterenol, and the increase in hexosamine-containing materials in the injured myocardium was investigated. Total hexosamine, galactosamine, neutral sugars, and uronic acids were determined on various fractions isolated from the hearts. Mucopolysaccharides were precipitated as the cetyl pyridinium chloride complex and fractionated according to their solubility in NaCl solutions. Of the hexosamine in the heart, approximately 50% was retained after proteolytic digestion and dialysis. Approximately one-fourth to one-third of the nondialyzable hexosamine was in mucopolysaccharides. The hyaluronic acid fraction of the mucopolysaccharides increased during the early edematous reaction observed in the hearts. The chondroitin sulfate fraction increased in conjunction with the beginning fibrinogenic processes and remained elevated during repair. There was evidence that the glycoproteins may be involved in the myocardial necrosis and repair.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
