Abstract
Adult, male Sprague-Dawley rats were given two daily injections of the potent beta-adrenergic stimulating agent, isoproterenol. Cardiac and plasma lactic acid levels were measured as an index of the degree of myocardial ischemia induced by isoproterenol. The first injection (Day 1) produced a prompt increase in both lactic acid levels which returned to normal in the blood but remained elevated in the heart tissue. The second injection (Day 2) did not cause any unusual increase in cardiac or plasma lactic acid levels. Histochemical fuchsinophilia, used as an index of glycolysis, acidosis, or lactic acid, coincided with the pattern of lactic acid changes determined chemically. These findings suggest that the myocardium of these animals has some capacity to make metabolic adjustments to compensate for the initial duress of isoproterenol stimulation. However, the second injection appears to be overwhelming, causing irreversible damage which progresses, unabated, to overt necrosis.
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