Abstract
Plasma adenosine, inosine and hypoxanthine concentrations were assayed in 7 controls, 5 myoadenylate deaminase deficient (MADD)patients and 6 McArdle patients before and after ischemic forearm exercise. The MADD patients showed a significantly lower increase of plasma inosine and hypoxanthine following exercise as compared to the controls, indicating diminished adenine nucleotide catabolism in the exercising MADD muscle. In the McArdle patients the increase in plasma inosine and hypoxanthine after exercise did not differ significantly from the values measured in the controls. The plasma adenosine increase was very low in all test groups and there were no significant differences.
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