Abstract
Polycystic ovary syndrome (PCOS) is one of the most common causes of subfertility, and it is characterized by hormonal dysregulation like insulin resistance. Various measures have been taken in the past to overcome this insulin resistance to improve fertility treatment outcomes. The current paper aims to review and compare the existing studies and literature to assess the impact of myo-inositol (MI) on oocyte and embryo quality in assisted reproductive technology (ARTs). We thoroughly searched the PubMed and Google Scholar databases by using the keywords “PCOS, polycystic ovarian syndrome, inositol, oocyte quality, embryo quality, assisted conception, ART, IVF, and in vitro fertilization.” Nine articles were finalized for review in this paper. Many of the reviewed studies have shown a trend toward the improvement of embryo quality in women with PCOS after MI supplementation; however, there is a lack of statistically significant evidence to support the use of MI in enhancing the quality of oocyte and/or embryo. Clear evidence regarding the role of MI in enhancing the quality of oocyte and embryo in PCOS is limited. A well-controlled, large, randomized controlled trial is required to definitively accept or refute its role.
Highlights
BackgroundPolycystic ovary syndrome (PCOS) is a common reproductive condition associated with chronic anovulation; it commonly manifests as oligomenorrhea, irregular menstrual cycle, and androgen excess, with typical ovarian ultrasound features [1]
The current paper aims to review and compare the existing studies and literature to assess the impact of myo-inositol (MI) on oocyte and embryo quality in assisted reproductive technology (ARTs)
We thoroughly searched the PubMed and Google Scholar databases by using the keywords “PCOS, polycystic ovarian syndrome, inositol, oocyte quality, embryo quality, assisted conception, ART, IVF, and in vitro fertilization.”
Summary
Polycystic ovary syndrome (PCOS) is a common reproductive condition associated with chronic anovulation; it commonly manifests as oligomenorrhea, irregular menstrual cycle, and androgen excess, with typical ovarian ultrasound features [1]. It is the most prevalent cause of disorder of ovulation and subfertility in females and affects approximately 6-10% of childbearing women population [2]. Many recent studies have shifted interest toward the two main inositol stereoisomers out of the nine isomers of the inositol family, namely myo-inositol (MI) and D-chiro-inositol (DCI) This inositol complex acts as a second messenger of insulin signaling.
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