Abstract
Pregnancy is a complex process, featuring several necessary changes in women’s physiology. Most women undergo healthy pregnancies; even so, several women experience reduced fertility or pathologies related to the pregnancy. In the last years, researchers investigated several molecules as promoters of fertility. Among all, myo-inositol (myo-ins) represents a safe compound that proved useful in issues related to fertility and pregnancy. In fact, myo-ins participates in several signaling processes, including the pathways of insulin and gonadotropins, and, therefore, it is likely to positively affect fertility. In particular, several clinical trials demonstrate that its administration can have therapeutic effects in infertile women, and that it can also be useful as a preventive treatment during pregnancy. Particularly, myo-ins could prevent the onset of neural tube defects and the occurrence of gestational diabetes mellitus, promoting a trouble-free gestation. Due to the safety and efficiency of myo-ins, such a treatment may also substitute several pharmaceuticals, which are contraindicated in pregnancy.
Highlights
Inositol unbalance may lead to reduced fertility or pregnancy complications; its administration can be useful in the prevention and in the treatment of several pregnancyrelated pathologies
Major complications may emerge, threatening the health of the mother and the fetus. These conditions include gestational diabetes mellitus (GDM) and neural tube defects (NTDs), which arise from insulin resistance and altered cellular motility phenomena, respectively
They found a significantly lower systolic blood pressure in eNOS+/− mice supplemented with inositol in relation to the placebo-treated dams, but they did not detect a similar result in wild type obese mice
Summary
Pregnancy represents a delicate period during the life of a woman. From its pursuit to the delivery, several criticalities may emerge, even if the greater part are nowadays preventable or manageable by applying a correct treatment plan. Inositols are important molecules in promoting female fertility and in sustaining physiological pregnancy. They are a family of six-membered carbocyclic polyalcohols, with nine possible stereoisomers, among which myo-inositol (myo-ins) and D-chiro-inositol (D-chiro-ins) have an established role in human physiology. D -chiro-ins is the second most represented isomer, as it is commonly detectable as a minor constituent in almost all the tissues containing myo-ins [1]. In physiology, inositols and in phenomena of cytoskeletal rearrangement [8]. In physiology, inositols reprerepresent the mediators of important functions, including cellular energetic metabolism, sent the mediators of important functions, including cellular energetic metabolism, follicle follicle maturation with menstrual cycle progression, and cellular motility.
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