Myelosarcomatosis

Abstract

Summary 1.A case of an extremely rare disease in a child six and a half years old is presented in which the essential features are multiple malignant tumors throughout the skeletal system, gastrointestinal tract, kidneys, pancreas, and dura mater which histologically have the appearance of undifferentiated myeloid tissue. The blood revealed many atypical cells that resembled young lymphocytes but may have been myeloid in origin. 2.In an attempt to classify this case, a detailed clinical and pathologic differential diagnosis is presented. 3.Emphasis is placed upon the difficulty in separating certain cases of leucemia from neoplastic disease. 4.With a great deal of reservation I have classified this case myelosarcomatosis after Buschke and Hirschfeld. Summary 1.A case of an extremely rare disease in a child six and a half years old is presented in which the essential features are multiple malignant tumors throughout the skeletal system, gastrointestinal tract, kidneys, pancreas, and dura mater which histologically have the appearance of undifferentiated myeloid tissue. The blood revealed many atypical cells that resembled young lymphocytes but may have been myeloid in origin. 2.In an attempt to classify this case, a detailed clinical and pathologic differential diagnosis is presented. 3.Emphasis is placed upon the difficulty in separating certain cases of leucemia from neoplastic disease. 4.With a great deal of reservation I have classified this case myelosarcomatosis after Buschke and Hirschfeld.