Abstract
Biochemical and morphological evidence of a green particulate isolated for the first time from the leucocyte of normal human blood indicates that the particulate fulfills sufficient criteria to suggest that it is a lysosome. The presence of peroxidase, β-glucuronidase, and acid phosphatase, and the absence of enzymes of the electron transport system, support this. The human leucocytic lysosome is heavier than that reported for the guinea pig and lighter than that of the horse. Its distribution in a number of animal species as measured by the peroxidase content of the neutrophile suggests that its content per cell is remarkably constant in nature.
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