Abstract
We investigated the association between myeloperoxidase gene -463G > A polymorphism and premature coronary artery disease (CAD) in two Chinese population samples: 229 patients and 230 controls. Genotypes were determined by ligase detection reaction-polymerase chain reaction sequencing and the grouping technique. We found lower frequencies of both the A/A genotype and the A allele in patients (p < 0.05). Multivariate logistic regression showed that the risk of premature CAD in subjects carrying the AA genotype was reduced by 83% in relation to individuals carrying the G/G genotype (OR = 0.172, 95% CI: 0.057-0.526, p = 0.002). Our results indicate that -463G > A polymorphism of the myeloperoxidase gene is associated with premature CAD in Chinese individuals, suggesting that the AA genotype is a protective factor against premature CAD.
Highlights
Myeloperoxidase (MPO) is a peroxidase enzyme produced by white blood cells
Several studies have shown that the -463G/A, -129G/A, -V53F, -A332V, and -638C/A single nucleotide polymorphisms (SNPs) and MPO levels are risk factors in coronary artery disease (CAD) (Nikpoor et al, 2001; Brennan et al, 2003; Chevrier et al, 2003, 2006; Rutgers et al, 2003; Nicholls and Hazen, 2005; Stefanescu et al, 2008)
MPO gene -463G > A polymorphism was first proven to be associated with CAD in a study by Nikpoor et al, (2001), the inclusion criteria used were disputable, since coronary stenosis of 3 30% qualified this as being a CAD case
Summary
Myeloperoxidase (MPO) is a peroxidase enzyme produced by white blood cells (mainly neutrophil granulocytes and mononuclear cells). Several studies have shown that the -463G/A, -129G/A, -V53F, -A332V, and -638C/A SNPs and MPO levels are risk factors in coronary artery disease (CAD) (Nikpoor et al, 2001; Brennan et al, 2003; Chevrier et al, 2003, 2006; Rutgers et al, 2003; Nicholls and Hazen, 2005; Stefanescu et al, 2008).
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