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Abstract
Objectives To examine the effect of blood anticoagulation type on the myeloperoxidase (MPO) concentration. Design and methods MPO was measured in EDTA-plasma and matched heparin-plasma and serum samples collected from healthy volunteers. Results MPO concentrations in heparin-plasma and serum were higher than in EDTA-plasma (both P < 0.001). MPO in EDTA-plasma was not significantly correlated with MPO in either heparin-plasma or serum. Conclusions For MPO measurements, EDTA-plasma is the preferred specimen as it appears unaffected by ex vivo release of MPO from leukocytes.
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