Myeloperoxidase and troponin T are linked with myocardial infarction among young Indians.

Anoop Jaiswal

doi:10.6026/97320630018066

Abstract

It is of interest to document the correlation of myeloperoxidase (MPO) and Troponin T (TnT) in young Indian patients with myocardial infarction using epidemiological data. A study with 220 (110 case and 110 control) participants with Acute Coronary Syndrome (both males and females) was completed. Patients were identified using a pre-designed PROFORMA at the OPD and IPD of the Medicine Department at the Index Medical College & Hospital, Malwanchal University and Moti Lal Nehru Medical College and Swaroop Rani Nehru Hospital in India. MPO and TnT were measured using the Sandwich ELISA (Sandwich Enzyme linked immunosorbent Assay) kit. TnT (pg/ml) (Mean ± SD) were high in the case group than control 134.7 ± 8.57 vs 96.6 ± 2.82; F = 145.9; t = 44.3; p < 0.01). Moreover, MPO was 3-fold high in case group than control (157±30.1 and 42.4±14.82, respectively). The differences was found statistically significant (p<0.001). This suggests a link between TnT and MPO among young Indian patients with myocardial infarction.

Highlights

Myocardial infarction (MI) continues to be a significant problem in developed countries and is becoming an increasingly significant problem in developing countries [1]
MI is more common in people over the age of 45, it can affect young men and women
Polymorphisms in the myeloperoxidase gene have been linked to premature ischemic heart disease [16], ischemic heart disease intensity [17], and heart failure mortality [18]

Summary

Introduction

Myocardial infarction (MI) continues to be a significant problem in developed countries and is becoming an increasingly significant problem in developing countries [1]. Indians develop coronary artery disease (CAD) 5 to 10 years earlier than in other populations and the occurrence of first myocardial infarction before the age of 40 years is 5 to 10 folds higher [2]. Myocardial infarction (MI) is the most dangerous form of CHD (coronary heart disease), and it can cause immediate death. MI is more common in people over the age of 45, it can affect young men and women. There are increased levels of MPO and Troponin - T in patients with CHD [7]. It is of interest to document the correlation between myeloperoxidase and troponin T in young Indian patients with myocardial infarction

Methods

Results

Discussion

Conclusion