Abstract
yelomeningocele, themost severe form of spina bifida, is a defect of primary neurulation that results from the M failed fusion in the caudal region of the neural tube, the so-called neuropore, at 25e28 days of gestation (12). The resulting unclosed segment of the neural plate (the neural placode) floats on top of a cerebrospinal fluidefilled, membrane-bound sac (9). Established risk factors, such as previous affected pregnancies, inadequate maternal intake of folic acid, pregestational diabetes, use of some antiepileptic drugs, and somegenetic pathways, such as folateehomocysteine pathway genes, have been linked to primary neurulation failure. Other suspected maternal risk factors are vitamin B12 status, obesity, hyperthermia, and diarrhea (10).
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
