Abstract
In three equal groups of cases (57 each of myeloma, carcinoma of the breast, and other carcinoma) with bone lesions, the radiographs were scrutinized for the prevalence of various diagnostic signs. No sign pathognomonic of myeloma was found. Preservation of pedicles, despite erosion or collapse in vertebral bodies; significant expansion of bone; and well-defined areas of destruction in the skull; are all strongly suggestive of myeloma. A soft-tissue mass associated with a rib lesion is uncommon when the primary tumour is in the breast but with other carcinomas is as common as in myeloma. Increased bone density is less common in myeloma than in carcinoma but is occasionally seen.
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