Abstract
JIA is an umbrella term used to describe a heterogeneous group of diseases. To date no specific markers exist in clinical practice to predict disease activity & outcome. MRP 8/14 are calcium-binding proteins secreted by infiltrating phagocytes in synovial inflammation. Studies have shown that serum (Se) concentrations correlate sensitively & specifically with synovial inflammation in JIA. It is believed that they are predictive biomarkers that can identify subclinical disease activity, patients at risk of relapse during times of clinically inactive disease, and patients more likely to respond to Rx with MTX. To date there have been no studies looking specifically at their use in DA. Research Q(s) - 1. Are MRP8/14 accurate markers of inflammation in DA? 2. Do MRP 8/14 levels in Se correlate to Synovial Fluid (SF)?
Highlights
JIA is an umbrella term used to describe a heterogeneous group of diseases
32 children (20 JIA, 12 DA) had Se samples taken for CRP, ESR & MRP 8/14 levels at diagnosis. 14 of these children had paired Synovial Fluid (SF) samples taken
We have shown that CRP is a poor marker of disease activity in JIA & DA, so the need for a more specific biomarker is evident
Summary
JIA is an umbrella term used to describe a heterogeneous group of diseases. To date no specific markers exist in clinical practice to predict disease activity & outcome. MRP 8/14 are calcium-binding proteins secreted by infiltrating phagocytes in synovial inflammation. Studies have shown that serum (Se) concentrations correlate sensitively & with synovial inflammation in JIA. It is believed that they are predictive biomarkers that can identify subclinical disease activity, patients at risk of relapse during times of clinically inactive disease, and patients more likely to respond to Rx with MTX. To date there have been no studies looking at their use in DA. Are MRP8/14 accurate markers of inflammation in DA? 2. Do MRP 8/14 levels in Se correlate to Synovial Fluid (SF)?
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