Myelin Quantification in the Basal Ganglia and the Cerebral Peduncles of Human Brains

Abstract

Myelin plays a key role in sending the brain signal from one neuron to another. Without myelin, the brain signals cannot be transmitted properly, so the human brain cannot act according to the situation. Myelin segmentation and quantification is very important for children and adults. Even though many research works are being conducted about myelination, no work is available to segment and quantify myelin from conventional magnetic resonance images (MRI). Some quantitative MRI methods are available which need more time and cost. If it is possible to quantify myelin from conventional MRI, it will be very useful in the medical field. In this work, myelin volume is calculated from different slices of T1-IR-weighted magnetic resonance images that correspond to the basal ganglia and the cerebral peduncle regions of different datasets. The basal ganglia and the cerebral peduncles are the important regions of myelination.