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Abstract
We read with great interest the article by Yu et al,[1][1] which investigated the utility of myelin volume fraction, axon volume fraction, and G-ratio, which is the ratio of the inner-to-outer diameter of a nerve fiber, in the evaluation of WM in patients with MS. They used macromolecular tissue
Highlights
We read with great interest the article by Yu et al,[1] which investigated the utility of myelin volume fraction, axon volume fraction, and G-ratio, which is the ratio of the inner-toouter diameter of a nerve fiber, in the evaluation of WM in patients with MS
We thank Yu et al[1] for referring to our article entitled, “Analysis of White Matter Damage in Patients with Multiple Sclerosis via a Novel In Vivo MR Method for Measuring Myelin, Axons, and G-Ratio.”[2]. The myelin volume fraction used in our study was calculated from the R1 and R2 relaxation rates and proton density measured by synthetic MR imaging, by simulating a 4-compartment model: myelin volume fraction, cellular volume fraction, excess parenchymal water volume fraction, and free water volume fraction.[3]
Myelin volume fraction in the MS lesions in our study was lower than in their study, and they discussed this discrepancy possibly being because the 4-compartment model used in our study did not incorporate the partial volume pool to account for magnetization transfer effects
Summary
We read with great interest the article by Yu et al,[1] which investigated the utility of myelin volume fraction, axon volume fraction, and G-ratio, which is the ratio of the inner-toouter diameter of a nerve fiber, in the evaluation of WM in patients with MS.
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