Abstract
Objective:To investigate early diagnostic effects of serum myelin basic protein (MBP) and ischemic modified albumin (IMA) levels in patients with ischemic stroke.Methods:Fifty patients who presented to an emergency service with acute ischemic stroke between June 2013 to March 2014 were evaluated with the National Institute of Health Stroke Scale (NIHSS) and diffusion-weighted magnetic resonance imaging (MRI). Thirty four healthy cases were included as control group. All patients’ serum IMA and MBP level were assessed.Results:Mean IMA value was 0.52±0.25 cases with acute ischemic stroke and serum IMA levels were significantly higher than the control group (p<0.01). No statistical significance was observed between acute ischemic stroke group and control group related to the MBP serum levels (P>0.05). Statistically significant correlation was detected between the volumes of diffusion restriction on MRI and NIHSS score (P=0.002, r=0.43) and IMA (P=0.015, r=0.344) levels.Conclusions:We have found that serum IMA levels are elevated in acute ischemic stroke cases and these levels are correlated with the ischemic tissue volume. MBP levels do not increase in early period of stroke cases.
Highlights
Acute ischemic stroke is caused by sudden interruption of cerebral blood flow
The most important result of this study was that ischemic modified albumin (IMA) levels of acute ischemic stroke cases were higher than the control group
We think that it could be used for evaluation and referral to imaging units for diagnosis of suspected cases of acute ischemic stroke admitted to emergency services
Summary
Acute ischemic stroke is caused by sudden interruption of cerebral blood flow. Morbidity and mortality of acute ischemic stroke cases are still high besides the developments in the treatment. Early diagnosis is required for an effective reperfusion therapy.[1] minimization of the time passed between the correct diagnosis and the beginning of the symptoms is very important. Diagnostic evaluation of suspected acute ischemic stroke cases in emergency services requires technical equipment and time consuming methods such as brain computerized tomography (CT) or magnetic resonance imaging (MRI) that could be performed by trained personnel.[2]. Thrombolytic treatment which could decrease mortality and improve quality of life is carried out in the first 3 hours of acute ischemic stroke cases.
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