Abstract
A variety of drugs are widely used to treat fungal infections. Mostly they are products of chemical synthesis, but recently, due to the increased resistance of fungi to many synthetic drugs, the relevance of the use of herbal remedies in the complex treatment of both skin infections and deep mycoses has been increasing. The aim of our research was to study the chemical composition of the lyophilic extracts of Plantago media and Plantago altissima of the flora of Ukraine by HPLC and GLC-MS methods and also mycostatic activity of ethanol and lyophilic extracts of the studied plants. As a result of the research, aucubin iridoid was detected in the lyophilic extracts of both species. There were also detected 15 polyphenolic compounds among which prevails acteoside, plantamayoside, ferulic and chlorogenic acid. Alcohol and lyophilic extracts of P. media and P. altissima showed mycostatic activity to all studied strains of yeast, dermatophytic fungi and aspergillus. The mycostatic effect of alcoholic extracts of P. media and P. altissima was more evident in comparison with the mycostatic effect of lyophilic extracts. The most evident antifungal effect was presented by alcoholic extract of P. media in relation to the clinical strain of Aspergillus oryzae (18.0±1.0 mm), and alcoholic extract of P. altissima to the clinical strain of Malassezia sp. (18.0±0.5 mm). The data obtained indicate a wide range of mycostatic effects of Plantago media and Plantago altissima extracts and the prospectivity of these objects for practical use in medicine.
Highlights
Fungal infections or mycoses are among the most common infectious diseases that cause damage of skin [1].fungal infections remain a significant cause of morbidity and mortality despite advances in medicine and the emergence of new antifungal agents [2].A variety of drugs are widely used to treat fungal infections
The lyophilic extracts of plantain which we study contain 15 polyphenolic compounds related to flavonoids and hydroxycinnamic acids
The composition of the phenolic components of the lyophilic extracts of the two plantain species Plantago media and Plantago altissima and their quantitative content were determined by HPLC method
Summary
Fungal infections or mycoses are among the most common infectious diseases that cause damage of skin [1].fungal infections remain a significant cause of morbidity and mortality despite advances in medicine and the emergence of new antifungal agents [2].A variety of drugs are widely used to treat fungal infections. Fungal infections or mycoses are among the most common infectious diseases that cause damage of skin [1]. Fungal infections remain a significant cause of morbidity and mortality despite advances in medicine and the emergence of new antifungal agents [2]. A variety of drugs are widely used to treat fungal infections. They are products of chemical synthesis, but recently, due to the increased resistance of fungi to many synthetic drugs, the relevance of the use of herbal remedies in the complex treatment of both skin infections and deep mycoses has been increasing. It is associated with a complex, multicomponent composition and content of organic compounds of various classes with different mechanisms of antifungal action
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
