Abstract
MycoProtease-DB is an online MS SQL and CGI-PERL driven relational database that domiciles protease information of Mycobacterium tuberculosis (MTB) complex and Nontuberculous Mycobacteria (NTM), whose complete genome sequence is available. Our effort is to provide comprehensive information on proteases of 5 strains of Mycobacterium tuberculosis (H37Rv, H37Ra, CDC1551, F11 and KZN 1435), 3 strains of Mycobacterium bovis (AF2122/97, BCG Pasteur 1173P2 and BCG Tokyo 172) and 4 strains of NTM (Mycobacterium avium 104, Mycobacterium smegmatis MC2 155, Mycobacterium avium paratuberculosis K-10 and Nocardia farcinica IFM 10152) at gene, protein and structural level. MycoProtease-DB currently hosts 1324 proteases, which include 906 proteases from MTB complex with 237distinct proteases & 418 from NTM with 404 distinct proteases. Flexible database design and easy expandability & retrieval of information are the main features of MycoProtease-DB. All the data were validated with various online resources and published literatures for reliable serving as comprehensive resources of various Mycobacterial proteases.AvailabilityThe Database is publicly available at http://www.bicjbtdrc-mgims.in/MycoProtease-DB/
Highlights
Tuberculosis continues to be a major health problem worldwide and it is estimated that in 2011, nearly 8.7 million new cases of TB with 1.4 million deaths among HIV-negative people and an additional 0.43 million deaths from HIV-associated TB [1]
The MycoProtease-DB data and related information are stored in MS SQL relational database tables
Protease information was collected from MEROPS [6] followed by NCBI, UniProt [7], Kyoto Encyclopedia of Genes and Genomes (KEGG) [8], TubercuList [9] and published literatures for individual strain
Summary
Tuberculosis continues to be a major health problem worldwide and it is estimated that in 2011, nearly 8.7 million new cases of TB with 1.4 million deaths among HIV-negative people and an additional 0.43 million deaths from HIV-associated TB [1]. Our effort is to explore proteases of MTB complex and NTM at gene, protein and structural level. The MycoProtease-DB data and related information are stored in MS SQL relational database tables.
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