Abstract
The recommended treatment regimen for Mycobacterium avium complex pulmonary disease (MAC-PD) consists of three drugs: rifampicin, ethambutol, and azithromycin. IV amikacin can be added in the initial 2 to 3 months for patients with severe or recurrent disease.1 With the recommended treatment regimens, 65% of treated patients attain culture conversion2; the median time-to-culture-conversion amounted to 4 (range, 1 to 12) months in a previous study.3 Because culture conversion requires multiple negative cultures that need to be incubated for 8 weeks, it takes up to 8 months to demonstrate culture conversion.
Highlights
Indicator Tube Time-Toincubated for 8 weeks, it takes up to 8 months to demonstrate culture conversion.[4]
There is a clear need for a biomarker to predict earlier on whether
The use ofquantitative culture analysis has been suggested as a relative rapid biomarker of treatment response.[3,5]
Summary
Indicator Tube Time-Toincubated for 8 weeks, it takes up to 8 months to demonstrate culture conversion.[4]. Biomarker of treatment regimen is necessary to achieve it
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