Abstract
Mycobacterium bovis caused 3% of human tuberculosis cases in southwest Ireland during 1998–2006. Of 11 M. bovis strains genotyped, 9 belonged to common animal spoligotypes. Seven strains were from sputum and potential sources of human-centered disease transmission. Ten-locus variable-number tandem repeat typing gave unique strain profiles and would detect disease outbreaks.
Highlights
M. bovis strains genotyped, 9 belonged to common animal spoligotypes
Mycobacterium bovis caused 3% of human tuberculosis cases in southwest Ireland during 1998–2006
We studied strains of M. bovis isolated from humans in the Republic of Ireland, and we have defined an optimal set of markers using a combination of spoligotyping and VNTR
Summary
Mycobacterium bovis caused 3% of human tuberculosis cases in southwest Ireland during 1998–2006. B ovine tuberculosis occurs worldwide [1,2,3] It is caused by Mycobacterium bovis, a cattle-adapted member of the M. tuberculosis complex. The risk for M. bovis infection in humans has been reduced by a test-and-slaughter program in which infected cattle are identified and culled. In the 1980s, 4%–6% of all cases of laboratory-confirmed tuberculosis in southwest Ireland were caused by M. bovis [5].
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