Abstract
IntroductionThe incidence of laryngeal tuberculosis has increased gradually in recent years. Laryngeal tuberculosis has strong infectivity and atypical clinical manifestations. Hence, establishing the early diagnosis of laryngeal tuberculosis is considered difficult, resulting in the high rate of misdiagnosis of laryngeal tuberculosis and increased rates of tuberculosis infection.ObjectiveThis study aimed to describe a case of laryngeal tuberculosis detected using the mycobacteria gene chips technology, facilitating the early diagnosis and the treatment of laryngeal tuberculosis.Case presentationA 27-year-old woman presented with a 7-day history of hoarseness, with a normal routine blood chemistry test and chest computed tomography results. Histological analysis of the vocal cord biopsy showed granulomatous inflammation and the negative acid-fast stain test. The mycobacteria gene chips method was used to directly examine the vocal cord tissue treated with homogenate, and the Mycobacterium tuberculosis was successfully identified. Thus, the early diagnosis of laryngeal tuberculosis and the drug sensitivity of rifampin and isoniazid were confirmed. The patient recovered after undergoing a 1-year standard anti-tuberculosis therapy.ConclusionsMycobacterial identification on homogenised biopsy using the mycobacteria gene chips method significantly facilitates the early diagnosis and the treatment of tuberculosis.
Highlights
In recent years, the epidemic status of tuberculosis (TB) has gradually increased along with the human immunodeficiency virus (HIV) infection and an aging population [1,2]
The results showed that mycobacterium TB (MTB) was positive (Figure 3a), and the detection of resistance genes indicated that rifampin and isoniazid had a wild-type genotype (Figure 3b and c)
After 1 year of well-tolerated treatment, the patient recovered, and the hyperplastic lesion in the vocal cords completely disappeared under laryngoscopy (Figure 1b)
Summary
The epidemic status of tuberculosis (TB) has gradually increased along with the human immunodeficiency virus (HIV) infection and an aging population [1,2]. TB infections in the head and neck have increased significantly, in developing countries [4]. Laryngeal TB has strong infectivity and atypical clinical manifestations. Establishing the early diagnosis of laryngeal TB is considered difficult, resulting in the high rate of misdiagnosis of laryngeal TB and increased rates of TB infection. The clinical demand in establishing the diagnosis of laryngeal TB is. Diagnosis of laryngeal tuberculosis 509 considered difficult [6]. The gene chips technology has been widely used in TB diagnosis. We will introduce a case of laryngeal TB that was diagnosed early with the application of MTB gene chips technology, suggesting that a good treatment effect was obtained, facilitating the diagnosis and the treatment of laryngeal TB
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