Abstract
Rabbits infected with BCG, Runyon IV, human, and bovine tuberculosis strains showed detectable circulating antibodies after 1 week and for the ensuing 6–7 weeks. The antibody titers generally correlated with the intensity of the infection; highest titers occurred in animals with tuberculous involvement.Intraperitoneal infection of guinea pigs with human, bovine, avian, Runyon IV, and paratuberculosis strains resulted in both lesions and good bentonite titers. The proliferation "in vivo" of acid-fast organisms plays a definite role in the establishment of circulating antibodies.
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