Abstract
MYC and integrins interplay in colorectal cancer.
Highlights
MYC functions as a transcriptional regulator in association with its partner MAX; the MYC/MAX heterodimer binds to DNA in a sequence-specific manner to activate transcription
The regulation of gene transcription by MYC has been reviewed in detail [1, 2]
In colorectal cancer (CRC) cells, MYC positively regulates ITGA6 (Groulx et al, unpublished) and ITGB4 [4] expression supporting the notion that MYC transcriptional activity is cell contextdependent
Summary
MYC functions as a transcriptional regulator in association with its partner MAX; the MYC/MAX heterodimer binds to DNA in a sequence-specific manner to activate transcription. The MYC/MAX heterodimer binds to the consensus sequence 5’-CANNTG-3’ (E box) to regulate the transcription of genes [1].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
