Abstract
Myasthenia gravis (MG) is an autoimmune disease in which the peak incidence is among women of childbearing age. For this reason, there is an overlap between the occurrence of this disease and pregnancy. It is known that MG symptoms can worsen during pregnancy and postpartum, and that pregnancy has special characteristics in MG patients. Children born to myasthenic mothers are at risk of having transient neonatal myasthenia. We briefly review the main relationships between MG and pregnancy, and we make recommendations for MG therapy, pregnancy, delivery, breastfeeding and newborns.
Highlights
Myasthenia gravis (MG) is an autoimmune disorder that is caused by antibodies against the neuromuscular junction
Questions have arisen concerning the impact of MG on pregnancy, as well as of pregnancy on MG; and concerning the effect of medications used to treat MG on fetal development, mode of delivery, safety of breastfeeding and newborn care
We describe the main relationship between MG and pregnancy and we make recommendations for MG therapy, pregnancy, delivery, breastfeeding and newborns
Summary
Myasthenia gravis (MG) is an autoimmune disorder that is caused by antibodies against the neuromuscular junction. Prenatal counseling should be provided to all MG patients who are women in the reproductive age group. Questions have arisen concerning the impact of MG on pregnancy, as well as of pregnancy on MG; and concerning the effect of medications used to treat MG on fetal development, mode of delivery, safety of breastfeeding and newborn care. In this brief review, we describe the main relationship between MG and pregnancy and we make recommendations for MG therapy, pregnancy, delivery, breastfeeding and newborns
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