Mutli-Features Prediction of Protein Translational Modification Sites.

Abstract

Post translational modification plays a significiant role in the biological processing. The potential post translational modification is composed of the center sites and the adjacent amino acid residues which are fundamental protein sequence residues. It can be helpful to perform their biological functions and contribute to understanding the molecular mechanisms that are the foundations of protein design and drug design. The existing algorithms of predicting modified sites often have some shortcomings, such as lower stability and accuracy. In this paper, a combination of physical, chemical, statistical, and biological properties of a protein have been ulitized as the features, and a novel framework is proposed to predict a protein's post translational modification sites. The multi-layer neural network and support vector machine are invoked to predict the potential modified sites with the selected features that include the compositions of amino acid residues, the E-H description of protein segments, and several properties from the AAIndex database. Being aware of the possible redundant information, the feature selection is proposed in the propocessing step in this research. The experimental results show that the proposed method has the ability to improve the accuracy in this classification issue.