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Abstract
Multiphoton microscopy (MPM) plays important role in biological imaging for its low scattering nature, yet it typically requires high illumination intensity. Although time-stretch of the ultrashort pulse can achieve ultrahigh speed scanning and deep penetration, the near-infrared illumination yields a compromised resolution because of its long wavelength. Here, by combining structured illumination with up-conversion materials, a multiphoton up-conversion time-encoded structured illumination microscopy (MUTE-SIM) with the scanning rate of 50 MHz is developed, which overcomes the limitation on the resolution. The resolution limit of near-infrared light is surpassed by a factor of 223.3% with low illumination intensity. This imaging strategy provides an ultrafast, low intensity, super-resolution MPM approach imaging, which has great potential in deep-tissue with high spatial resolution.
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