Abstract
OBJECTIVE: Defects in mismatch repair (MMR) genes are associated with genomic instability and development of cancer. MMR mutation carriers are also at high risk for extracolonic malignancies as occurs in Lynch syndrome. Interestingly, MMR (Pms2, Mlh3 and Mlh1)-deficient mice display infertility associated with abnormal chromosome pairing in meiosis. MSH5 is a MutS homolog that plays an important functional role in meiotic recombination during Holliday Junction (HoJo) formation. MSH4 interacts with MSH5 forming a heterodimer that uniquely binds to the HoJo crossover region, suggesting a role in both recombination and crossover interference.
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