Abstract
We report mutations in influenza A virus (H5N1) strains associated with 2 outbreaks in Turkey. Four novel amino acid changes (Q447L, N556K, and R46K in RNA polymerase and S133A in hemagglutinin) were detected in virus isolates from 2 siblings who died.
Highlights
Influenza A virus (H5N1) is the predominant candidate for a future influenza pandemic if it develops efficient ability for human-to-human transmission
Human viral isolates FK and MAK were obtained from 2 siblings who died shortly after the
Amino acids at positions [16, 13, 18, 20, 28, 55], and 78 in matrix 2 (M2) are associated with host specificity; those at positions [31, 34, 26, 27], and 30 are associated with resistance to adamantanes (2)
Summary
Influenza A virus (H5N1) is the predominant candidate for a future influenza pandemic if it develops efficient ability for human-to-human transmission. The Study We analyzed molecular evolution of the virus genome by sequencing the hemagglutinin (HA), RNA polymerase (PB2), and matrix 2 (M2) genomic segments of 4 chicken and 2 human viral isolates. The MYS viral isolate was obtained from a chicken. Viral isolates SU, 13, and 20 were obtained from chickens in southeastern Turkey, Anatolia, and Istanbul, respectively.
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