Abstract
Intense transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Africa might promote emergence of variants. We describe 10 SARS-CoV-2 lineages in Benin during early 2021 that harbored mutations associated with variants of concern. Benin-derived SARS-CoV-2 strains were more efficiently neutralized by antibodies derived from vaccinees than patients, warranting accelerated vaccination in Africa.
Highlights
Anna-Lena Sander,1 Anges Yadouleton,1 Edmilson F. de Oliveira Filho, Carine Tchibozo, Gildas Hounkanrin, Yvette Badou, Praise Adewumi, Keke K
Genomic surveillance is key to elucidate coronavirus disease (COVID-19) transmission chains and to monitor emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants as
Lineage assignment using the Pangolin COVID-19 Lineage Assigner version 3.0.2 confirmed single-nucleotide polymorphism (SNP)-based lineage prediction in all 9 typeable samples selected for whole-genome sequencing (Appendix Table 2)
Summary
Anna-Lena Sander,[1] Anges Yadouleton,[1] Edmilson F. de Oliveira Filho, Carine Tchibozo, Gildas Hounkanrin, Yvette Badou, Praise Adewumi, Keke K. We analyzed SARS-CoV-2 genomic diversity in Benin ≈1 year later and assessed the ability of vaccinee-derived and patient-derived serum samples to neutralize SARS-CoV-2 variants. The Study We used 378 SARS-CoV-2–positive diagnostic respiratory samples tested at the reference laboratory in Benin during January 30–April 2, 2021, for genomic surveillance.
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