Abstract
Ocular lymphomas can be divided into intraocular lymphomas involving vitreous, retina known as vitreoretinal lymphoma which is usually diffuse large B-cell lymphoma (DLBCL), whereas ocular adnexal lymphomas involving orbit, conjunctiva, lacrimal gland, eyelid, and uveal lymphomas are usually extranodal marginal zone B-cell lymphoma (EMZL). Confirming the diagnosis of ocular and adnexal lymphoma is quite difficult. Cytopathologic examination, the standard diagnostic procedure, suffers from very low sensitivity due to the limited number of cells, preceding corticosteroid therapy, and the rapid degeneration of lymphoma cells. The biological background of ocular and adnexal lymphoma is largely unknown; therefore, understanding its genomic landscape could be the first step in clarifying its pathogenesis, diagnosis, prognosis, and treatment.
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