Abstract
The CLC-ec1 is a bacterial homologue of the transporter-type CLC subclass that catalyzes transmembrane exchange of Cl− and H+. Gluex (E148 in CLC-ec1) is the pH-dependent external gate of both Cl− and H+ transport. The central tyrosine, Y445 (Tyrcen) coordinates the central Cl− ion and acts as the internal gate of the Cl− pathway. Gluin (E203) is remotely located to the internal Cl− gate and acts as the internal proton-transfer residue that delivers protons from the internal aqueous solution to the protein interior.
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